Saccharin-Induced Sister Chromatid Exchanges in Chinese Hamster and Human Cells
- 5 May 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4341) , 543-545
- https://doi.org/10.1126/science.644315
Abstract
Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.Keywords
This publication has 11 references indexed in Scilit:
- Long-term toxicity of ortho-toluenesulfonamide and sodium saccharin in the ratToxicology and Applied Pharmacology, 1980
- Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cellsNature, 1977
- Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. I. In vivo test for compounds requiring metabolic activationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their useNature, 1976
- The mutagenicity of saccharinMutation Research/Reviews in Genetic Toxicology, 1975
- Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomesMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Cytological detection of mutagen–carcinogen exposure by sister chromatid exchangeNature, 1975
- New Giemsa method for the differential staining of sister chromatidsNature, 1974
- Differential giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiographyChromosoma, 1974