Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use
- 1 December 1976
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 264 (5587) , 624-627
- https://doi.org/10.1038/264624a0
Abstract
Six short term tests for detecting carcinogenicity have been evaluated using 120 compounds, of which half were carcinogens and the rest non-carcinogens. The results obtained indicate that the Ames test and a “cell transformation” assay are both sufficiently sensitive to carcinogenicity, or the lack of it, in the compounds studied to enable them to be employed for detecting potential carcinogens. The consequences of using short term tests under various screening conditions have been explored. In order to have confidence in the results obtained for new or previously untested compounds it is important to use such tests in a carefully controlled manner.This publication has 10 references indexed in Scilit:
- Short term screening tests for carcinogensNature, 1976
- Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.Proceedings of the National Academy of Sciences, 1975
- Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1975
- The Cancer ProblemScientific American, 1975
- Lost OpportunityScience, 1975
- Disruption by Carcinogens of the Hormone Dependent Association of Membranes with PolysomesNature, 1971
- Agar suspension culture for the selective assay of cells transformed by polyoma virusVirology, 1964
- REACTION OF CARCINOGENS WITH ACRIDINEProceedings of the National Academy of Sciences, 1961
- ON THE ELECTRON DONATING PROPERTIES OF CARCINOGENSProceedings of the National Academy of Sciences, 1960
- A SURVEY OF COMPOUNDS FOR ACTIVITY IN THE SUPPRESSION OF MOUSE SEBACEOUS GLANDS1958