Sensitivity of thermoacidophilic archaebacteria to α-sarcin

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Abstract
The protein synthesis machinery of Sulfolobus solfataricus, a thermoacidophilic archaebacterium, is insensitive to most of the known antibiotics that interfere with elongation. α-Sarcin, a cytotoxic protein, inhibits protein synthesis on eukaryotic systems by cleaving a specific sequence of the large rRNA. α-Sarcin is capable of inhibiting protein synthesis on S. solfataricus producing a fragment under conditions similar to those which produce it in yeast ribosomes. This result suggests the presence on S. solfataricus of the sequence necessary for the enzymatic hydrolysis promoted by α-sarcin.