Two allelic forms of mouse beta 2-microglobulin.

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Abstract
Two allelic forms of mouse .beta.2-microglobulin (.beta.2m), the small polypeptide chain of H-2 histocompatibility antigens, were identified. The 2 forms can be distinguished by NaDodSO4/polyacrylamide gel electrophoresis. All inbred mouse strains express a single .beta.2m isotype. Mice heterozygous for .beta.2m synthesize both forms, showing codominant expression of .beta.2m alleles. In mice heterozygous for both H-2 and .beta.2m, individual H-2 histocompatibility antigens associate with both .beta.2m forms. Preliminary structural studies indicate differences in peptide composition between the 2 forms.