THE ADRENOGENITAL SYNDROME IN CHILDREN A CLINICAL AND STEROID METABOLIC STUDY

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Abstract
The urinary 17 ketosteroid excretion of 3 boys, 3 to 5 yrs. old with adrenogenital syndrome and a newborn female infant with pseudohermaphroditism were detd. The chromatographic patterns from the 3 boys were almost identical, but that obtained from the girl was of a different type. During cortisone treatment the 17-ketosteroid excretion was depressed and the chromatographic pattern changed. In the case of the boys, virilization was apparently caused by large amounts of androsterone. No ketosteroids could be identified in the urine of the girl with pseudohermaphroditism. Also detd. were 17-hydroxycorticosteroids and eosinophils. These were all correlated with the clinical results.