THE EFFECT OF PREGNANCY ON THE SURVIVAL OF SKIN HOMOGRAFTS IN RABBITS

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Abstract
SUMMARY: 1. Rabbit-skin homografts transplanted to recipients that are between 20 and 24 days pregnant survive for about twice as long as do homografts transplanted to pregnant rabbits early or late in pregnancy or to normal males or females. 2. Pregnancy does not interfere with the manifestation of a pre-existing immunity to a donor's skin. 3. The results are taken to provide evidence that the production of corticosteroids is increased during pregnancy. Possible sources of such increased production are discussed. 4. It is suggested that adrenocortical hormones may help to protect the foetus from the immunological consequences of its genetic incompatibility with the mother.

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