Rapid Communication: Human Peripheral Myelin Protein‐22 Carries the L2/HNK‐1 Carbohydrate Adhesion Epitope
- 1 November 1993
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 61 (5) , 1961-1964
- https://doi.org/10.1111/j.1471-4159.1993.tb09840.x
Abstract
Molecular genetic studies have established that mutations in the gene encoding the 22-kDa peripheral myelin protein (PMP-22) are responsible for hereditary peripheral neuropathies in the trembler mouse and in a subset of humans with Charcot-Marie-Tooth disease, type 1a. The function of the PMP-22 protein remains unknown. Several studies on myelin proteins in the PNS have indicated that the L2/HNK-1 epitope, which is believed to be both a ligand for cellular adhesion and a target for autoimmune monoclonal IgM neuritis, may be found on heretofore unidentified proteins with a molecular mass of 19–28 kDa. In this report, we provide immunological evidence that at least one of these proteins is PMP-22.Keywords
This publication has 21 references indexed in Scilit:
- Progress in the molecular understanding of hereditary peripheral neuropathies reveals new insights into the biology of the peripheral nervous systemTrends in Neurosciences, 1993
- DNA deletion associated with hereditary neuropathy with liability to pressure palsiesCell, 1993
- L2/HNK‐1 carbohydrate and protein‐protein interactions mediate the homophilic binding of the neural adhesion molecule P0Journal of Neuroscience Research, 1992
- The gene for the peripheral myelin protein PMP–22 is a candidate for Charcot–Marie–Tooth disease type 1ANature Genetics, 1992
- Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13)The Journal of cell biology, 1992
- Developmentally and spatially regulated expression of HNK-1 carbohydrate antigen on a novel phosphatidylinositol-anchored glycoprotein in rat brain.The Journal of cell biology, 1991
- The Epitope(s) Recognized by HNK‐1 Antibody and IgM Paraprotein in Neuropathy Is Present on Several N‐Linked Oligosaccharide Structures on Human P0 and Myelin‐Associated GlycoproteinJournal of Neurochemistry, 1990
- Characterization of HNK‐1 bearing glycoproteins in human peripheral nerve myelinJournal of Neuroscience Research, 1990
- The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions.The Journal of cell biology, 1988
- Immunological Nonidentity of 19K Protein and TP0 in Peripheral Nervous System MyelinJournal of Neurochemistry, 1986