LOW-DENSITY MONONUCLEAR CELLS

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Abstract
Purification strategies similar to those used to purify murine dendritic cells were applied to human peripheral blood to enrich for stimulators of the human mixed lymphocyte reaction (MLR). Equilibrium density centrifugation of peripheral blood mononuclear cells yields a population of low density cells that are potent stimulators of a human MLR. The stimulator cells are Dr+, nonlymphocytic and weakly adherent. Strongly adherent monocytes, also present in the low-density cell population, do not stimulate a human MLR. This contrasts with other human MLR studies that ascribe stimulatory activity to adherent monocytes. Functional and morphological heterogeneity among monocytes was indicated.

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