HB Luxembourg [α24(B5) Tyr→His]: A New Unstable Variant

1 January 1989

journal article
research article
Published by Taylor & Francis in Hemoglobin

Vol. 13 (5) , 429-436
https://doi.org/10.3109/03630268908998082

Abstract

Hb Luxembourg (.alpha.24(B5)Tyr .fwdarw. His] was found in association with mild hemolytic anemia and increased indirect bilirubinemia in a family originating from the Netherlands. The slight instability of this variant may be the consequence of an indirect effect of the substitution on the .alpha.1.beta.1 contact since position .alpha.24 (B5) is internal and in contact with several residues involved in this interface.

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