Amyotrophic lateral sclerosis
- 1 July 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (7) , 948
- https://doi.org/10.1212/wnl.36.7.948
Abstract
We studied the reticular dermis in patients with amyotrophic lateral sclerosis (ALS) and controls with or without neurologic diseases. By light microscopy, collagen bundles in ALS dermis were reduced in amount and more loosely woven than in controls. Electronmicroscopy revealed a significant negative correlation between duration of illness and the diameter of collagen fibrils in patients with ALS. There was also a marked increase of amorphous material positive for ruthenium red in the ground substance. These findings were not observed in controls.This publication has 12 references indexed in Scilit:
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