The heterogeneity and differential expression of protein kinase C in nervous tissues
- 26 July 1988
- journal article
- research article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 320 (1199) , 313-324
- https://doi.org/10.1098/rstb.1988.0079
Abstract
Protein kinase C exists as a large family of multiple subspecies with subtle individual characteristics. This heterogeneity comes from different genes as well as from different splicings of a single RNA transcript. The members of this family have closely related structures with a high degree of homology. Biochemical studies have shown that their mode of activation and kinetic and catalytic properties differ slightly from one another. By using a combination of biochemical and immunocytochemical techniques, their differential regional and cellular expression have been shown in the nervous tissues. Each member of this enzyme family may have a specialized function in transducing various physiological and pathological signals into different cell types.This publication has 38 references indexed in Scilit:
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