High-Pressure Liquid Chromatographic Determination of Thioridazine and Its Major Metabolites in Biological Tissues and Fluids

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Abstract
A method is described for the determination of thioridazine and its major metabolites in postmortem tissues and fluids by enzymic digestion, followed by a micro-extraction technique using ethyl acetate. Quantitation was performed by using a cyano-bonded silica (µ Bondapak-CN) column packing and a mobile phase consisting of n-octylamine, methanol, and water.