Effect of butaclamol, a new neuroleptic, on serotoninergic mechanisms

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Abstract
Butaclamol (1·0–0·1 mg kg−1, i.p.) and spiroperidol (1·0–0·5 mg kg−1, i.p.), but not (—)-butaclamol (15 mg kg−1, i.p.), blocked the hyperactivity induced in rats by tranylcypromine-l-tryptophan pretreatment. Neither butaclamol nor spiroperidol altered the accumulation of brain 5-HT following pargyline or the decline of brain 5-HT following inhibition with the tryptophan hydroxylase inhibitor α-propyldopacetamide thus indicating that butaclamol and spiroperidol do not affect either the synthesis or the turnover of brain 5-HT. It is concluded that the antagonism of the tranylcypromine-l-tryptophan-induced hyperactivity by butaclamol and spiroperidol is due to their blockade of dopaminergic receptors rather than an action on neuronal serotoninergic mechanisms.

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