A new view of the spindle checkpoint
Open Access
- 3 September 2001
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 154 (5) , 909-912
- https://doi.org/10.1083/jcb.200108010
Abstract
Previous studies of the spindle checkpoint suggested that its ability to prevent entry into anaphase was mediated by the inhibition of the anaphase-promoting complex (APC) ubiquitin ligase by Mad2. Two new studies challenge that view by demonstrating that another checkpoint protein, BubR1, is a far more potent inhibitor of APC function.Keywords
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