The Effect of Whole Body X Radiation on the Natural Sheep Cell Hemolysin of the Rabbit

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Abstract
Whole body X-radiation of rabbits with 500 r and 700 r produced a significant decline in natural sheep red cell hemolysin. The decline cannot be attributed to absorption by antigens diffusing or invading from a damaged intestinal tract and is probably due to a decreased production combined with a naturally rapid metabolic decay. Assuming this to be true, postirradiation decline in natural antibodies would be most evident in those species whose globulins have a generally high turnover rate. Where antibodies have different rates of metabolic decay, X-radiation effects should be most pronounced in the antibody with the shortest biological half-life.

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