NONRANDOM LOSS OF MATERNAL CHROMOSOME-11 ALLELES IN WILMS-TUMORS
- 1 May 1987
- journal article
- research article
- Vol. 40 (5) , 413-420
Abstract
A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from (1) five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and (2) their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.This publication has 24 references indexed in Scilit:
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