Unstructured Two‐Point Estimation of One‐Compartment Linear Pharmacokinetic Parameters

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Abstract
A method is described which estimates one‐compartment linear pharmacokinetic parameters from two serum drug concentrations obtained at any known times during a drug regimen. During multidose regimens, these two samples need not have a specific temporal relationship to a particular dose. Also, the method will predict eventual steady‐state drug concentrations early in the course of a continuous infusion. Modifications of the basic method will accommodate variations in the dosage regimen and permit the analysis of data in patients who have measurable serum drug concentrations prior to the start of the regimen.