Genetic Influence of the Rs Locus on Susceptibility to Avian Tumor Viruses. II. Rous Sarcoma Virus Antibody Production After Strain RPL12 Virus Inoculation

Publisher Website
Google Scholar
Abstract
Chickens resistant to the Bryan standard strain of Rous sarcoma virus (BS-RSV), because they are of the homozygous recessive (rs rs) genotype at the Rs locus, produced much lower levels of specific BS-RSV neutralizing antibody after inoculation with the antigenically related RPL12 lymphomatosis-erythroblastosis virus than did chickens of susceptible genotypes (Rs Rs or Rs rs). Our interpretation is that the RPL12 virus does not replicate enough in resistant chickens to produce sufficient viral antigen to invoke a strong immune response. The occurrence of within-species genetic variation in specific cellular resistance to a parasite is discussed.

This publication has 14 references indexed in Scilit: