Effect of Total Body Irradiation on Iron Metabolism in Human Bone Marrow

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Abstract
Results of haematological and iron metabolism investigations on 17 patients who received total body X irradiation are presented. In vivo iron tracer studies indicate that 25 to 50 r total body irradiation to man 24 hours before an injection of 59Fe does not delay the appearance of the radioactive iron in the peripheral erythrocytes. One hundred röntgens total body irradiation to man does not delay the appearance of 59Fe in the peripheral erythrocytes if the tracer is given two hours after the irradiation, but if the tracer is given 24 to 72 hours after irradiation there is a definite delay in the appearance of the 59Fe in the erythrocytes. The probable mechanisms for producing the delay in the appearance of the 59Fe in the peripheral erythrocytes are discussed.