Preferential Induction of Jones-Mote Hypersensitivity in Guinea Pigs Treated with Tolerogenic Antigen

Open Access
Publisher Website
Google Scholar
Abstract
Effects of tolerogenic form of bovine γ-globulin (BGG) on the Jones-Mote hypersensitivity, tuberculin hypersensitivity, and helper function were studied in guinea pigs. 1) When intermediate or large doses of tolerogenic BGG were injected i.v. on day -14 or 0 and immunogenic BGG in complete Freund's adjuvant (CFA) was injected subcutaneously on day 0, tuberculin hypersensitivity and helper function were depressed, although Jones-Mote hypersensitivity was preserved or augmented. Jones-Mote hypersensitivity was suppressed with the uppermost dose of tolerogenic BGG. Suppressing mechanism(s) to Jones-Mote hypersensitivity appears to be slightly more resistant to tolerance induction than tuberculin hypersensitivity and helper function and more sensitive than Jones-Mote hypersensitivity. 2) Expression of tolerant states was not absolute but relative to the doses of immunogenic BGG. When a larger amount of immunogenic BGG was given, larger amounts of tolerogenic BGG were required to obtain the same degrees of tolerance as that expressed in animals given a smaller amount of immunogenic BGG. 3) In animals in which immune responses were suppressed partially with tolerogenic BGG, tuberculin or Jones-Mote hypersensitivity was delayed in the development. 4) Basophils comprised more than half of the infiltrating cells at the sites of erythematous reactions elicited in the animals showing the tolerant states of tuberculin hypersensitivity and helper function. Thus, typical Jones-Mote hypersensitivity was raised preferentially in the tolerant states of other types of immune responses. These findings may be explained by different affinities to BGG among T cell subpopulations responsible for individual responses and individual cells within a subpopulation for each response.