PROPERTIES OF GUINEA PIG 7S ANTIBODIES

Open Access

1 June 1963

journal article
research article
Published by Rockefeller University Press in The Journal of Experimental Medicine

Vol. 117 (6) , 951-964
https://doi.org/10.1084/jem.117.6.951

Abstract

Guinea pig 7Sγ₁ antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ₂ antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ₂ antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.

Keywords

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The Journal of Experimental Medicine, 1963
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