Potentiation of Bleomycin Lethality by Anticalmodulin Drugs: A Role for Calmodulin in DNA Repair
- 22 June 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 224 (4655) , 1346-1348
- https://doi.org/10.1126/science.6203171
Abstract
Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.This publication has 14 references indexed in Scilit:
- Changes in calmodulin and its mrna accompany reentry of quiescent (G0) cells into the cell cycleCell, 1984
- Cations and calmodulin in normal and neoplastic cell growth regulationCanadian Journal of Biochemistry and Cell Biology, 1983
- Inhibition of Glia maturation factor-induced mitogenesis in glioblasts by calmodulin antagonistsBrain Research, 1983
- Interferon affects intracellular calmodulin levelsBiochemical and Biophysical Research Communications, 1983
- Calmodulin and cell proliferationBiochemical and Biophysical Research Communications, 1982
- Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progressionCell, 1982
- The Effect of Inhibition of (ADP‐ribose)n Biosynthesis on DNA Repair Assayed by the Nucleoid TechniqueEuropean Journal of Biochemistry, 1981
- An increase in calmodulin during growth of normal and cancerous liver in vivoFEBS Letters, 1981
- DNA polymerase III-dependent repair synthesis in response to bleomycin in toluene-treated Escherichia coliMolecular Genetics and Genomics, 1980