Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers
- 1 March 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 271 (5253) , 1289-1291
- https://doi.org/10.1126/science.271.5253.1289
Abstract
In mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to establish this lymphoid structure are derived from bone marrow.Keywords
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