Mediation by G Proteins of Signals That Cause Collapse of Growth Cones
- 1 January 1993
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 259 (5091) , 77-79
- https://doi.org/10.1126/science.8418498
Abstract
During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.Keywords
This publication has 29 references indexed in Scilit:
- Removing constraints on neural sproutingCurrent Biology, 1992
- Repellent cues in axon guidanceCurrent Opinion in Neurobiology, 1992
- Molecular Mechanisms of Axon Growth and GuidanceAnnual Review of Cell Biology, 1991
- The neuronal growth cone as a specialized transduction systemBioEssays, 1991
- Growth cone inhibition – an important mechanism in neural development?BioEssays, 1991
- Molecular Mechanisms Of Axon Growth And GuidanceAnnual Review of Cell and Developmental Biology, 1991
- A common denominator of growth cone guidance and collapse?Trends in Neurosciences, 1990
- The p38 and p34 polypeptides of growth cone particle membranes are the α- and β-subunits of G proteinsDevelopmental Brain Research, 1990
- Axonal guidance in the chick visual system: Posterior tectal membanes induce collapse of growth cones from the temporal retinaNeuron, 1990
- Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult RatsScience, 1981