Contrasting roles of 5‐hydroxytryptamine and noradrenaline in fever in rats.

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Abstract
The effects of endogenous monoamine depletion on the development of fever in rats was investigated. Fever was produced in rats by a single i.p. injection of Salmonella typhosa endotoxin or leukocyte pyrogen manufactured from ox blood. Depletion of brain 5-hydroxytryptamine (5-HT [serotonin]) by pretreatment with p-chlorophenylalanine prevented the rise in rectal temperature produced both by bacterial endotoxin and by leukocyte pyrogen. Depletion of noradrenaline (NA [norepinephrine]) by 6-hydroxydopamine pretreatment resulted in a potentiation of the fever produced by bacterial endotoxin. 5-HT is apparently involved in mechanisms responsible for the rise in temperature during fever. NA is apparently involved in mechanisms which serve to attenuate the rise.