Simple model for the DNA denaturation transition
- 1 September 2000
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review E
- Vol. 62 (3) , 3958-3973
- https://doi.org/10.1103/physreve.62.3958
Abstract
We study pairs of interacting self-avoiding walks on the simple cubic lattice. They have a common origin and are allowed to overlap only at the same monomer position along the chain: for while is allowed. The latter overlaps are indeed favored by an energetic gain ε. This is inspired by a model introduced long ago by Poland and Sheraga [J. Chem. Phys. 45, 1464 (1966)] for the denaturation transition in DNA where, however, self avoidance was not fully taken into account. For both models, there exists a temperature above which the entropic advantage to open up overcomes the energy gained by forming tightly bound two-stranded structures. Numerical simulations of our model indicate that the transition is of first order (the energy density is discontinuous), but the analog of the surface tension vanishes and the scaling laws near the transition point are exactly those of a second-order transition with crossover exponent Numerical and exact analytic results show that the transition is second order in modified models where the self-avoidance is partially or completely neglected.
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This publication has 29 references indexed in Scilit:
- Thermal denaturation of DNA molecules: A comparison of theory with experimentPublished by Elsevier ,2002
- Statistical Mechanics of Torque Induced Denaturation of DNAPhysical Review Letters, 1999
- Helicoidal model for DNA openingPhysics Letters A, 1999
- Entropy-driven transition in a one-dimensional systemPhysical Review E, 1995
- Entropy-driven DNA denaturationPhysical Review E, 1993
- Occurrence of a Phase Transition in Nucleic Acid ModelsThe Journal of Chemical Physics, 1966
- Phase Transitions in One Dimension and the Helix—Coil Transition in Polyamino AcidsThe Journal of Chemical Physics, 1966
- Effect of Excluded Volume on Phase Transitions in BiopolymersThe Journal of Chemical Physics, 1966
- Theory of ``Melting'' of the Helical Form in Double Chains of the DNA TypeThe Journal of Chemical Physics, 1960
- Theory of the Phase Transition between Helix and Random Coil in Polypeptide ChainsThe Journal of Chemical Physics, 1959