THE EFFECTS OF HYPOPHYSECTOMY, GROWTH AND ADRENOCORTICOTROPIC HORMONES ON THE INCORPORATION OF P32INTO LIVER PHOSPHOLIPIDS

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Abstract
IT HAS been reported that growth hormone causes an increase of liver fat during fasting (Szego and White, 1949; Li, Simpson and Evans, 1949), and that administration of adrenocorticotropic hormone results in a marked increase of fat content in the liver (Baker, Ingle, Li and Evans, 1948; Li, Ingle, Evans, Prestrud and Nezamis, 1949). On the other hand, hypophysectomy does not influence the fat content of the liver (Chaikoff, Entenman, Gillman, and Reichert, 1948). It would, therefore, seem apparent that the anterior lobe of the pituitary must in some way influence fat mobilization and metabolism. The present investigation concerns a study on the phospholipid fraction of the liver and attempts to elucidate the role of anterior pituitary hormones in lipid metabolism. EXPERIMENTAL Three separate experiments were carried out. The first was designed to study the effects of ageing on phospholipid P32 incorporation: normal male rats (Long-Evans strain, 25, 55, and 240 days of age) were used.