ILEAL RESECTION POTENTIATES 1,2-DIMETHYLHYDRAZINE-INDUCED COLONIC CARCINOGENESIS
- 1 January 1979
- journal article
- research article
- Vol. 189 (4) , 503-508
Abstract
The effect of colonic hyperplasia produced by resection of the distal third of the small bowel (DSBR) on the development of chemical carcinogenesis of the colon by dimethylhydrazine (DMH) was tested in rats. For the most part the amounts of RNA and DNA in the small bowel were the same with the combined treatments as with either one alone. Quantities of nucleic acids tended to increase only in transverse and distal colon. After 37 wk the number of neoplasms per rat was increased 6-fold by combining DSBR with DMH. Neoplasms were spread throughout the colon after combined treatment as opposed to the ascending colon after DMH alone. Postresectional hyperplasia appears to increase the incidence and distribution of colon tumors.This publication has 24 references indexed in Scilit:
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