Adiabatic Pumping Mechanism for Ion Motive ATPases

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Abstract
An ion motive ATPase is a membrane protein that pumps ions across the membrane at the expense of the chemical energy of adenosine triphosphate (ATP) hydrolysis. Here we describe how an external electric field, by inducing transitions between several protein configurations, can also power this pump. The underlying mechanism may be very similar to that of a recently constructed adiabatic electron pump [M. Switkes et al., Science 283, 1905 (1999)].