MACROPHAGE-LYMPHOCYTE INTERACTION IN MIGRATION-INHIBITION FACTOR (MIF) PRODUCTION AGAINST SOLUBLE OR CELLULAR TUMOR-ASSOCIATED ANTIGENS .1. CHARACTERISTICS AND GENETIC-CONTROL OF 2 DIFFERENT MECHANISMS OF STIMULATING MIF PRODUCTION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 121  (2) , 695-701
Abstract
For [mouse] MIF production in response to 3 M KCl extracts of tumor, viable and metabolically active macrophages [M.vphi.] were required to interact with the soluble tumor antigens and then come in contact with immune lymphocytes. The M.vphi.-lymphocyte interaction for MIF production was under the control of genes mapping in the IA subregion of the H-2 complex. When intact tumor cells were used as antigen, M.vphi. were not required for immune lymphocytes to produce MIF. The interaction of immune lymphocytes with tumor cells for MIF production did not require H-2 compatibility. These and other observations strongly suggest that there are 2 different mechanisms for MIF production and that these may be mediated by 2 separate subpopulations of immune lymphocytes.