Hyaluronan and cell locomotion
- 1 March 1992
- journal article
- review article
- Published by Springer Nature in Cancer and Metastasis Reviews
- Vol. 11 (1) , 21-30
- https://doi.org/10.1007/bf00047600
Abstract
Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA: RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.Keywords
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