Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage
- 1 August 1994
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 42 (1-2) , 71-73
- https://doi.org/10.1007/bf02014303
Abstract
Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.Keywords
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