Olfactory neuroblastoma: A retrospective clinicopathologic study

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Abstract
Twenty‐one cases of olfactory neuroblastoma treated at The University of Michigan Hospitals between 1945 and 1981 were reviewed with emphasis on the method of treatment and outcome. Staging of the cases by the method of Kadish and co‐workers was done. The clinical course was not predictable on the basis of the histologic criteria. Local recurrences were common (61%). Metastatic spread of the neoplasms occurred in 28% of the cases. The recurrence‐free interval decreased in those patients treated initially with radiation as compared with those treated with surgery alone. This study does not support the premise that radiation treatment is as good as surgery in early disease. Craniofacial resection combined with radiation treatment for recurrence is the preferred treatment.