Monoclonal antibody analysis of blood T-cell subsets in multiple sclerosis

Publisher Website
Google Scholar
Abstract
The present study deals with the characterization of peripheral blood T-cell subpopulations in multiple sclerosis (MS) patients during different stages of the disease. An indirect immunofluorescence assay was performed using monoclonal antibodies directed at lymphocyte surface antigens. Patients in exacerbation were found to have significantly (p < 0.001) reduced OKT 8 + (T-suppressor) cells and a high helper/suppressor ratio (p < 0.001). Patients in remission showed a significant increase of suppressor T-cells compared to controls (p < 0.02) and patients during relapse (p < 0.001); H/S ratio was consequently low compared to acute MS (p < 0.001) and controls (p < 0.1). Patients with a progressive course showed an intermediate T-subset pattern. The results are discussed in the light of the most recent neuroimmunological approaches to MS. Sono state studiate le sottopopolazioni linfocitarie nel sangue di pazienti con sclerosi multipla in diverse fasi della malattia. I pazienti in fase di ricadute hanno mostrato una significativa (p + (T-soppressori) ed un elevato rapporto induttori/soppressori (p . Al contrario, i pazienti in remissione hanno mostrato un significativo aumento dei T-soppressori rispetto ai controlli (p . I pazienti con decorso progressivo hanno mostrato un quadro delle sottopopolazioni T-linfocitarie, intermedio rispetto a quelli descritti. Tali risultati sono stati discussi alla luce delle più recenti acquisizioni neuroimmunologiche sulla Sclerosi Multipla.