HEMODYNAMIC EFFECTS OF 1-HYDRAZINOPHTHALAZINE (APRESOLINE) IN HUMAN PREGNANCY: RESULTS OF INTRAVENOUS ADMINISTRATION 1

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Abstract
The hemodynamic effects of intraven. apresoline (20-40 mg.) were studied in 75 subjects including 12 normotensive non-pregnant women, 12 normotensive pregnant subjects, 33 with toxemia of pregnancy, and 18 pregnant patients with essential hypertension. The hypotensive effect of the drug was more marked and prolonged in patients with toxemia of pregnancy, the avg. fall in blood pressure being 30% of the control systolic level and 45% of the control diastolic level. A significant increase in cardiac output occurred at the height of hypotension in toxemic patients, and the total peripheral and pulmonary arteriolar resistances were reduced without change in blood volume. The temp. of the upper extremities, face,and anterior chest wall rose significantly but there was little change in that of the lower extremities. The vasopressor response to cold, observed during the control period was unchanged after apresoline admn. and the valsalva "overshoot" was not affected. The effect of epinephrine was not inhibited or reversed. Its hemodynamic effects indicate that it may be a valuable adjunct in treating toxemia of pregnancy.

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