Cataractogenesis in Infant Rats with Model Phenylketonuria
- 1 August 1972
- journal article
- research article
- Published by SAGE Publications in Perceptual and Motor Skills
- Vol. 35 (1) , 47-49
- https://doi.org/10.2466/pms.1972.35.1.47
Abstract
Parachlorophenylalanine was employed to produce phenylketonuria (PKU) in immature rats. Blood phenylalanine, liver phenylalanine hydroxylase and behavioral abnormalities were found. In addition, severe lenticular clouding was observed, a phenomenon not seen when model PKU was induced by means of L-phenylalanine. Surgical removal of the eyelids prior to normal eye opening (12 to 14 days) resulted in fulminating cataractous development in both treated and untreated rats as soon as light entered the eye. Animals allowed to open eyes at normal time differed in that the treated rats showed cataract while none was seen in untreated controls.Keywords
This publication has 5 references indexed in Scilit:
- Acute reversible lens opacity: Caused by drugs, cold, anoxia, asphyxia, stress, death and dehydrationExperimental Eye Research, 1970
- Ocular Studies With Para-chlorophenylalanine in Rats and MonkeysArchives of Ophthalmology (1950), 1970
- Phenylalanine antimetabolite effect on development — I. Behavioral effects of , -4-chlorophenylalanine in the young ratLife Sciences, 1969
- p -Chlorophenylalanine-Induced Chemical Manifestations of Phenylketonuria in RatsScience, 1967
- Phenylketonuria: Enduring Behavioral Deficits in Phenylketonuric RatsScience, 1967