Supersensitivity after intraventricular 6-hydroxydopamine: Relation to dopamine depletion
- 1 April 1980
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (4) , 436-438
- https://doi.org/10.1007/bf01975133
Abstract
6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA utake in rat striatum. The increase response to apomorphine, however, only occurred after greater than 80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.Keywords
This publication has 18 references indexed in Scilit:
- A radioenzymatic assay for catecholamines and dihydroxyphenylacetic acidLife Sciences, 1978
- Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral SupersensitivityScience, 1977
- Selective activation of the mesocortical DA system by stressNature, 1976
- Cholinergic and dopaminergic blocking agents modulate water intake elicited by deprivation, hypovolemia, hypertonicity and IsoproterenolPharmacology Biochemistry and Behavior, 1975
- Neuroleptic-induced deficits in food and water regulation: Similarities to the lateral hypothalamic syndromePsychopharmacology, 1975
- Neurochemical evidence for denervation supersensitivity: The effect of unilateral substantia nigra lesions on apomorphine-induced increases in neostriatal acetylcholine levelsLife Sciences, 1974
- Turning behavior of mice with unilateral 6-hydroxydopamine lesions in the striatum: Effects of apomorphine, l-DOPA, amantadine, amphetamine and other psychomotor stimulantsNeuropharmacology, 1973
- Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in RatsScience, 1972
- Altered response to apomorphine in 6-hydroxydopamine-treated ratsEuropean Journal of Pharmacology, 1972
- Mode of action of apomorphine and dexamphetamine on gnawing compulsion in ratsPsychopharmacology, 1967