Meningeal Tumors Induced in Calves with the Bovine Cutaneous Papilloma Virus

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Abstract
Fibromatous tumors were induced in the meninges of calves by inoculating the meninges with a suspension of bovine cutaneous papillomas or by implanting bovine cutaneous papillomas into the brain. Meningeal tumors were observed to occur as early as 20 days after inoculation. Meningeal tumors from calves killed 90 and 145 days after inoculation extended into the brain along the course of blood vessels. Metastasis, however, was not observed. Evidence that the induced meningeal tumors contained viral antigen was lacking.