EFFECT OF DIETARY CHANGES UPON URINE VOLUME AND RENAL FUNCTION IN EXPERIMENTAL DIABETES INSIPIDUS

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Abstract
In diabetes insipidus, there is a deficiency in ability to concentrate either NaCl or nitrogenous compounds in the urine. The latter are more important than the former in the maintenance of the polyuria under ordinary dietary conditions, because nitrogenous substances form the major portion of the total solids of the urine. In both dogs and cats with d.i., the polyuria varied directly with the sum of the osmotic activities of the NaCl and nitrogenous compounds in the urine. Nitrogen partition detns. showed no evidence of any abnormality in N metabolism in d.i. Creatinine clearance studies showed that the changes in urine flow accompanying alterations in protein intake extended into the postabsorp-tive period, after glomerular filtration had returned to the level observed postabsorptively on a control diet. Post-absorptive tubular reabsorption of water, however, was greater on a low N diet, and less on a high protein diet, than the control. This is interpreted on the basis of the osmotic effect of the nitrogenous substances present in the tubular fluid.

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