Phosphotriester Synthesis of Oligonucleotides with the Use of N- and O-Nucleophilic Intramolecular Catalysis
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1-2) , 279-282
- https://doi.org/10.1080/07328318708056204
Abstract
An effective method for the synthesis of oligonucleotides by the phosphotriester approach has been developed. It is based on the use of phosphate protecting groups enabling O-nucleophilic intramolecular catalysis.Keywords
This publication has 4 references indexed in Scilit:
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- Highly efficient oligodeoxyribonucleotide synthesis using fully base protected phosphodiester building blocks carrying 2-(l-methylimidazol-2-yl)phenyl protection of the phosphateNucleic Acids Research, 1986
- Improved rapid phosphotriester synthesis of oligodeoxyribonueleotides using oxygen-nucleoplillic cataiystsNucleic Acids Research, 1985
- 1-Methyl-2-(2-hydroxyphenyl)imidazole: a catalytic phosphate protecting group in deoxyoligonucleotide synthesisJournal of the American Chemical Society, 1985