Modulation of Macrophage Tumoricidal Capability by Components of Normal Serum: A Central Role for Lipid
- 15 July 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4300) , 282-285
- https://doi.org/10.1126/science.195338
Abstract
The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.This publication has 26 references indexed in Scilit:
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