Collagen and Cellular Proliferation in Spontaneous Canine Benign Prostatic Hypertrophy

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Abstract
To define an animal model for the study of cellular and extracellular matrix accumulation in human benign hypertrophy (BPH), cell number and levels of collagen and Zn were measured in normal and spontaneously hypertrophied canine prostate glands. The increased gland weight in canine BPH was accompanied by increased contents of DNA, collagen and Zn. Concentrations of collagen and Zn in BPH did not differ from normal. Apparently, canine BPH involves true hyperplasia and may represent an overgrowth of normal cellular and extracellular components. Canine BPH may prove to be a useful animal model for study not only of cellular proliferation, but also of the connective tissue and Zn accumulation in the human disease.