Transannular dioxygenation of 9,10-dimethyl-1,2-benzanthracene by cytochrome P-450 oxygenase of rat liver
- 15 December 1976
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 160 (3) , 805-808
- https://doi.org/10.1042/bj1600805
Abstract
The carcinogen 9,10-dimethyl-1,2-benzanthracene is oxygenated by rat liver microsomal cytochrome P-450 oxygenase to its 9,10-epidioxide. This transannular 1,4-peroxide is converted further into the diol by the microsomal preparation and NADPH. These 2 products constitute the majority of the metabolites found under the conditions described.This publication has 12 references indexed in Scilit:
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