ANTIGEN-PRESENTING PROPERTIES OF HUMAN VASCULAR ENDOTHELIAL-CELLS - INHIBITION BY ANTI-HLA-DR ANTISERA

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 14  (5) , 545-553
Abstract
Human vascular endothelial cells (EC) separated from the umbilical vein are capable of presenting antigen to in vivo-sensitized T cells, leading to an immunoproliferative response to various antigens in vitro. Optimal T cell response was only observed when the EC donor shared both HLA-D/DR determinants with the T cell donor. The T cell response normally observed when using antigen-pulsed EC was significantly and specifically inhibited by xeno- and allo-antisera reacting with the HLA-DR molecules. Antibodies reacting with the native antigen determinants (rubella virus) also appeared capable of inhibiting the response elicited by primed T cells to antigen-pulsed EC.