New era of calpain research
- 18 April 1994
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 343 (1) , 1-5
- https://doi.org/10.1016/0014-5793(94)80595-4
Abstract
The recent discovery of several new calpain species other than the two species thus far studied reveals that calpain, especially the calpain large subunit, constitutes a family comprising at least six members that can be classified into ubiquitous (μ-, m- and -types) and tissue-specific (p94 or nCL-1 specific for skeletal muscle, and nCL-2 and -2' specific for stomach) calpains. The newly identified tissue-specific calpains have various characteristics distinct from conventional calpains in structure, manner of expression, and enzyme activity. Unique features of tissuespecific calpains are discussed together with the evolutionary view of the calpain large subunit.
Keywords
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