COMPARATIVE EFFECT OF INTRAVENOUS GLUCOSE AND ADRENALIN ON BLOOD FLOW, OXYGEN UTILIZATION AND GLUCOSE RETENTION BY HIND LEG TISSUES OF ANESTHETIZED CATS

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Abstract
Intraven. injn. into dial-urethanized cats, of adrenalin at the rate of 0. 004 mg. /kg. /min. for 5 min. and of glucose at the rate of 0. 05 g. /kg. /min. for 5 min. produced hyperglycemias of marked avg. similarity +77 and +82 mg. %, respectively. From these hyperglycemic blood sugar levels glucose transfer from blood to leg tissues was increased 120 and 88% by adrenalin and glucose, respectively; so that adrenalin at least did not inhibit this effect. The avg. effect of adrenalin on blood flow through the leg was to increase it 3%; of glucose, 28%. Both might in individual instances cause either an increase or a decrease; but after glucose the increases were more common and of greater degree. Oxygen utilization by the leg tissues followed the change in blood flow rather than of glucose uptake; thus, glucose injn. increased it 19% and adrenalin injn. only 5%. Records of arterial blood pressure, heart rate and leg volume (plethysmograph) were obtained and used in an effort to account for the observed changes in leg blood flow.

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