How should diagnostic tests be evaluated in glaucoma?

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Abstract
Most diagnostic studies in glaucoma have employed a case-control design similar to the one used in the work by Reus et al,1 including glaucoma patients (cases), defined based on the presence of repeatable characteristic glaucomatous visual field defects; and normal subjects (controls), generally required to have normal visual fields, normal intraocular pressures and healthy appearance of the optic nerve. These studies are clearly important to provide an initial exploratory …