EFFECT OF CARRAGEENAN ON THE INDUCTION OF CELL-MEDIATED CYTO-TOXIC RESPONSES INVIVO

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (2) , 297-302
Abstract
Carrageenan (CAR), a sulfated polygalactose having macrophage toxic properties, elicited a suppression of primary cytotoxic T lymphocyte (CTL) responses against allogeneic tumor cells in the spleen when the tumor cells ([mouse lymphoma] EL-4 tumor cells, H-2b) were administered s.c. to AKR mice. When the allogeneic tumor cells were administered i.v. to AKR mice, CTL responses to the alloantigens were not detected in the spleen, but were detected in the peritoneal exudate cells. CAR treatment suppressed the responses. In vitro secondary CTL responses of cells from alloantigen-primed mice were markedly enhanced by the pretreatment of such mice with CAR. Two steps, macrophage-dependent and independent, probably are involved in the development of CTL responses in vivo.