TEMPORAL TRANSITION IN SITE OF RAT ERYTHROPOIETIN PRODUCTION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 5  (5) , 399-407
Abstract
Plasma erythropoietin levels were determined in nephrectomized, hepatectomized, nephrectomized and hepatectomized, and intact hypoxia rats.sbd.1, 2, 3 and 8 wk of age. The liver appears to be the primary site of erythropoietin production during the first 2 wk of life. By the 3rd wk, the kidneys began producing erythropoietin and by 8 wk, they were the major organs of erythropoietin production. Indirect immunofluorescent staining for erythropoietin of renal and hepatic tissue correlated with the results of the erythropoietin bioassay. Fluorescent staining of glomerular cells in the kidney and macrophages or Kupffer cells in the liver implicate these areas as possible specific sites of erythropoietin production.

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