Coding strategy differences between constant and variable segments of immunoglobulin genes
Open Access
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (13) , 5515-5527
- https://doi.org/10.1093/nar/12.13.5515
Abstract
Vertebrate immunoglobulin (Ig) mRNAs reveal intraspecies variation in codon usage distinct from that seen with yeast or bacterial genes. Comparison of all available Ig gene sequences shows that %(G+C) in codon position III is consistently lower in variable (V) segments than in constant (C) segments. I find an even lower %(G+C) in the hypervariable domains of V segments. This analysis suggests that base substitution in Ig genes correlates positively with local A+T content.Keywords
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